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MEBO Wound Ointment

Brand: MEBO
Product Code: 2
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Availability:
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Price: $23.00 Ex Tax: $23.00
Applications: 
  Acute Wounds 
- Burn wounds including first degree, superficial second-degree, deep second-degree superficial type, deep second-degree deep type, superficial third-degree and deep third-       degree burn wounds, burn wounds on bone, electronic burns and severe chemical burns (Typical Clincal Cases Profiles)
- Surgical wounds including donor site wounds, cosmetic surgical wounds, ostomy wounds, wounds of circumcision, obstetrical wounds 
- Pressure wounds 
- Amputated limbs 
  Chronic Wounds (Typical Clinical Cases Profiles) 
- Diabetic ulcers 
- Pressure ulcers 
- Soft tissue necrosis 
- Chemotherapeutic phlebitis 
- Radioepidermitis 
- Herpes zoster 
- Newborn diaper dermatitis 
- Common warts 
Product Advantages: 
   Maintains wound in a physiological moist environment 
   Promotes wound healing by activating and sustaining intrinsic regenerative potential of the body and cultivating stem cells of the body in situ and in vivo 
   Improves wound microcirculation in the zone of stasis 
   Protects wounds from potential infection 
   Minimizes pain and the use of analgesics 
   Restores physiological structure and function of the body 
   Promotes quality of healing by reducing scarring 
Specification:
   Botanical drug consisting of multiple botanic components and nutritional ingredients cooperated with patented dosage form with net-frame structure. Topical ointment made from natural ingredients including sesame oil, beeswax, and other edible herbs, which provide β-sitosterol, 18 natural amino acids, 4 essential fatty acids, vitamin E, and polysaccharides. 
   Each tube contains 20 g or 40 g of ointment 
   Ointment is yellow with a sesame scent.
 
 

1.Superficial burn and superficial partial-thickness burn regeneration

       1.1 First degree burns

The clinical signs of first-degree burns include skin redness, slight swelling and pain. Immediate application of MEBO may relieve the pain. The erythema gradually diminishes as MEBO is warmed in situ and absorbed through the skin. At 12h postburn, the skin may return to normal. For burns with edema, the epidermis is partially destroyed, the pains may be relieved more slowly and the wounds would heal in 2~4 days when the superficial stratum corneum exfoliates.

       Step 1. Ⅰ degree burn, skin redness, slight swelling and pain

       

       Step 2. Apply MEBO immediately postburn. With the absorption of MEBO, pain is relieved and edema fades away gradually. Continue applying MEBO.

       

       Step 3. Two to three days later, burned skin would heal. Continue apply MEBO as a protective ointment for about one week so as to fully restore normal skin functions.

       

2.Second degree burn regeneration

       2.1 Superficial second degree burns

Apply MEBO directly on wounds in 4 hours postburn. The thickness of medicine should not thicker than 1mm and redress the wounds every 4-6 hours. Clean residues on wounds and exudates with disinfectant gauze before redressing each time. Generally, wounds will cure in 6-7 days. For wounds with blisters, release water in blisters at low position and do not remove the blister skin. Remove the blister skin 3-4 days postburn and continue applying MEBO. Seven days later, wounds wound heal.

       Step 1. Apply MEBO with thickness less than 1mm. Release water in blisters at low position and do not remove the blister skin

        

       Step 2. Three to four days later, remove the blister skin and apply MEBO immediately. Smear MEBO along the direction of fine hair gently to relieve stimulations.

        

       Step 3. Four to six hours after applying MEBO, a layer of white liquefied exudates was formed. It is a normal phenomenon of excreting necrotic skin tissues (Do not take it as infection).

        

       Step 4. Clean the liquefied products with no injury. Redress MEBO with no pains, bleeding or damage to live tissues on wounds.

        

       Step 5. Alternatively, use disinfected gauze to absorb liquefied products for 30 seconds or 1 minute.

        

       Step 6. Disclose gauze along tangential direction.

        

       Step 7. Clean the liquefied products completely.

        

       Step 8. Smear MEBO evenly on wounds. The thickness is less than 1mm.

        

       Step 9. Seven days later, wounds would heal. Apply MEBO as a protective ointment for 7-10 days so as to restore normal skin function.

        

3.Deep partial-thickness burn regeneration superficial type

Clinical signs include wound pain, extensive blisters, wound without blister skin becoming red and white, necrotic or white superficial dermal tissue, and red survival deep dermis tissue. A thin layer of soft membrane may appear on the wound. Reserve the layer of membrane and continue applying MEBO every 4-5 hours every day. Five days later, clean the membrane and redress complying with the principle of “Three No”. The necrotic tissues are all liquefied and discharged from wounds 10-15 days postburn. 20 days later, wounds regenerate and repair to heal. Continue applying MEBO for 10-15 days as protective oil until skin functions are restored to normal.

       Step 1. On 1st day postburn, wounds are superficial Ⅱ degree burns mixed with deep Ⅱ degree burns. There are blisters in different sizes. Release water in blister and retain blister skin.

        

       Step 2. Apply MEBO directly and protect wounds.

        

       Step 3. On 3rd day postburn, apply MEBO on wounds. Edema fade away and a layer of soft membrane forms on wounds.

       

       Step 4. On 4th day postburn, superficial Ⅱ degree burns gradually heal. Necrotic tissues are liquefied on deep Ⅱ degree superficial type wounds. Redress MEBO every 4 hours (6-8 hours at night) and remove the soft membrane.

         

       Step 5. On 8th day postburn, deep Ⅱ degree superficial wounds continue being liquefied. Clean the liquefied products and necrotic skin complying with the principle of ‘Three No’ before redressing MEBO.

       

       Step 6. On 12th day postburn, necrotic tissues are liquefied and discharged. Under protection of fabric isolating membrane, wounds are repaired to heal.

       

       Step 7. On 15th day postburn, most wounds are repaired to heal.

       

       Step 8. On 25th day postburn, all wounds heal. Continue using MEBO as protective ointment for 10-15 days until skin functions are restored.

        

4.Deep partial-thickness burn regeneration deep type

At early stage, the treatment is the same as that for deep second superficial type degree burns. Remove the necrotic skin 5 days later. Because the dermis layer has been injured, wounds appear wax-like white. Continue applying MEBO with the thickness of less than 1mm. Redress every 4 hours. After applying MEBO, there would be liquefied necrotic tissues exudates on wounds. It is a normal phenomenon and do not take it as infection. Remember to clean the residual drug and white liquefied exudates on wounds with disinfected gauze before redressing each time. About 15 days later, necrotic tissues are liquefied and discharged. Then a layer of fabric isolating membrane on wounds should form. Continue applying MEBO according to method mentioned above to protect the layer of membrane until wounds are healed with flat skin. If wounds are not healed after being treated for more than three weeks, it shows that the wound is superficial third degree burn and should be treated with corresponding method.

       Step 1. After simple debridement, apply MEBO immediately to protect wounds.

         

       Step 2. On 5th day postburn, remove necrotic skin. Necrotic tissues on wounds are liquefied and discharged.

        

       Step 3. A layer of fabric isolating membrane forms on wounds under the action of MEBO.

        

       Step 4. Apply MEBO complying with the principle of ‘Three No’ and protect the membrane to promote repairing of wounds.

       

       Step 5. On 30th day postburn, burn wounds regenerate and repair.

       

       Step 6. Continue applying MEBO for 10-15 days to protect healed skin.

        

5.Healing process of using MEBT/MEBO in deep second degree burns in cellular level

To study the physiological healing process, histological examination was performed on tissue samples taken from deep second-degree burn patients under the treatment using MEBT/MEBO.  Xu “Physiological Healing Procedure and Histological Observation on Deep Second-Degree Burns Treated with MEBO” Burns Regenerative Medicine and Therapy, 1st ed., Basel: Karger; 2004. p.106-111.

Six cases were enrolled throughout the study, 5 males and 1 female, aged from 21 to 36 years-old.  Total burns surface area varied from 12% to 45%, with an average of 24.33±12.37%.  All patients were admitted within 6 h post-burn.  After admission, patients received fluid resuscitation and antibacterial therapy on the basis of burn severity.  Burns wounds were applied with MEBO at a thickness of 1 mm, which was repeated every 4-6 h till wound was healed. 

As shown in Figure 1.2.1.1, the tissue at the wound site underwent dramatic patho-morphological changes during the treatment using MEBT/MEBO.  Under the conditions provided by MEBO wound ointment, pathological changes of the deep second-degree burn wounds can be divided into three stages: (1) denaturation and necrosis of injured tissue, (2) liquefaction and discharge of the denatured and necrotic tissues, and (3) restoration of physiological structure and function of the skin.  These stages may overlap.  As shown in Figure 1.2.1h, the newly regenerated skin has virtually an identical morphology and structure to that of non-injured skin.  No skin grafting was performed.  

       

       

       

       

       

       

6.Full-thickness burn regeneration

       6.1 Superficial full-thickness burn treatment

Apply “skin cultivating and tension relieving” method to relieve the pressure of necrotic skin for deeper tissues. Apply MEBO to protect burn wounds and facilitate the transformation of potential regenerative cells into stem cells. Liquefy and discharge necrotic dermis tissues under the function of MEBO, cultivate new skin tissues in situ to cover wounds and form new skin tissues to allow wounds heal naturally.

       Step 1. Superficial Ⅲ degree flame burn on face. No pain. No exudates.

       

       Step 2. Cultivate and decompress on burned skin with ‘Plough Saw Blade’.

        

       Step 3. After cultivating, tension is decompressed and some red liquid exudates emerged. Then smear MEBO directly and apply MEBT.

        

       Step 4. On 12th day postburn, necrotic tissues are liquefied and discharged under the action of MEBO.

       

       Step 5. On 18th day postburn, necrotic skin is liquefied and discharged. Absorb liquefied products with gauze. Pay attention to protect fabric isolating membrane on wound.

        

       Step 6. On 27th day postburn, some part of wounds is repaired to heal while the other parts are still in recovery process.

       

       Step 7. On 50th day, new skin regenerate and wounds heal. Apply MEBO as protective ointment for 15-30 days.

 

       Step 8. On 72nd day postburn, all Ⅲ degree burn wounds are repaird to heal physiologically.

        

       6.2 Deep full-thickness burn treatment

For small area third-degree burns, first of all apply MEBO to protect wounds and then use ‘plough saw blade’ to decompress necrotic skin. Treat wounds complying with the method for deep second degree burns. For large area burns, apply the method mentioned above when the patient is in stable vital signs.

       Step 1. Ⅲ degree burn with area of 85% TBSA. The pathological section on right side shows full-thickness skin necrosis.

        

       Step 2. Apply cultivating and tension relieving method on Ⅲ degree wounds in chest. Apply MEBT/MEBO to treat.

        

       Step 3. Clean liquefied necrotic tissues in time and treat wounds complying with the principle of treating deep Ⅱ degree burns.

        

       Step 4. On 20th day postburn, burned necrotic tissues are liquefied and discharged. A layer of membrane forms on wounds. The pathological section shows that wounds were repaired by regenerative skin tissues.

        

       Step 5. Under the protection of MEBO and membrane, regenerative skin tissues form dense skin islands.

       

       Step 6. Pathological section: stem cells regenerate and repair skin in situ.

       

       Step 7. ‘Skin islands’ gradually extend to normal skin tissues.

       

       Step 8. On 49th day postburn, the pathological section of healed skin shows structure of normal skin.

        

       Step 9. On 72nd day postburn, whole layers of skin regenerate, repair and heal.

        

7.Healing process of using MEBT/MEBO in full-thickness burns in cellular level

As described in detail by Xu in “Clinical Procedure and Histological Observation of Full-Thickness Burns Treated with MEBO” in Burns Regenerative Medicine and Therapy, 1st ed., Basel: Karger; 2004. p. 111-114, MEBT/MEBO was used to treat a patient with extensive full-thickness burns in her lower extremities. 

A 20-year-old female patient was hospitalized at 12 h after a gasoline fire burn and was diagnosed with 35% TBSA burn (15% deep partial-thickness and 20% full-thickness burns on both lower extremities).  The epidermis was necrotic and detached and the dermal layer was degenerated and necrotic with a waxy yellow and waxy white appearance (Figure 1.2.2.1a).  The pathological section examination of the sampled local wound tissues revealed a necrosis in full-thickness of epidermis and dermis, degeneration and structural disturbance of collagenous fibers in dermis, and microcirculation stasis (Figure 1.2.2.1b). 

After admission, the patient was treated with MEBT/MEBO wound ointment to protect burn tissue.  At 48 h postburn, the wounds began to liquefy and the liquefaction was complete by day 4 (Figure 1.2.2.2).  The liquefied products were gently removed from the wound surface before MEBO ointment was reapplied every 3-4 h.  Repeat biopsy at the same burned location was performed for pathological examination.  The results showed massive granulation tissues among the necrotic epithelial tissue, a proliferation of newly regenerated epithelial cells with collagenous fibers, as well as the typical skin embryonic base (EB) (Figure 1.2.2.3a, b).  After a 10-day application of MEBO ointment, embryonic-like epithelial tissues were observed in epithelial tissues sampled from the wound edge.  At 20 days post-treatment with MEBO, the pathological examination of deep burns wounds tissue showed the presence of the newly formed intact stratified squamous epithelium.  The epithelial cells of the superficial layer appeared normal.  Appearance of the collencytes and microangium in the dermis layer was typical.  On day 30 post-treatment, epithelial tissues showed a remarkable degree of regeneration (Figure 1.2.2.4a), and skin structure was virtually normal (Figure 1.2.2.4b).

       

       

       

       

Twenty days post treatment with MEBO, immunohistochemical examination of the wound tissue was performed and the results showed the clear appearance of collagenous fibers in epithelial tissue and subcutaneous tissue (Figure 1.2.2.5).

       

       

       

       

       

       

Twenty (20) days post-treatment, appearance of the hemidesmosome junction between the basal cell layer and epithelia was observed.  Active mitochondria and RER in fibroblasts also appeared (Figures 1.2.2.8a-c).  Thirty (30) days post-treatment with MEBO ointment, with the regeneration and repairing of epithelium almost complete, collagenous fibers were mature with a diameter of 0.1-0.5 μm and arranged in an orderly fashion (Figure 1.2.2.9).  Light and dark periodic cross-striation (64 nm) was also observed.  No pathomorphological changes of collagenous fibers such as distortion, helicoid (whirlpool) or cauliflower-like form were observed.  After wound healing, functional exercises and physiotherapy of the lower extremities were performed.  MEBO wound ointment was used continuously as regular skin oil.  The patient healed and was discharged home on day 45 postburn.

       

       

       

       7.1 Pig model

To evaluate the efficacy of MEBO wound ointment on tissue repair and regeneration, preclinical studies were carried out in pig models for burn wounds as compared with that of local wound care agents commonly used in wound treatment.  Ioannovich et al. “Moist Exposed Burn Therapy: Evaluation of the Epithelial Repair Process (an Experimental Model)” Annal of Burns and Fire Disasters 2000: XIII (J):3-9. Eighty (80) partial-thickness burn wounds on 10 Ladrace-Pietrenne young pigs were induce by CO2 laser. 

As shown in Figure 1.1.1 below 8 partial-thickness burn wounds of different depths measuring 5 x 5 cm were inflicted on either side of the paravertebral region in each pig (total number of burn wounds: 80).

       

       

       

       

Attribute №1
Expiry Date 2 years
Attribute №2
Net Content 40g
Attribute №3
Package tube

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